Abstract
Six children with documented idiopathic or secondary deficiency of growth hormone (GH) received amobarbital (3-5 mg/kg p.o.) before and six weeks after replacement therapy with human growth hormone (hGH). In order to determine whether hepatic microsomal oxidizing ability was affected by hGH, the volume of distribution (V), half-life (T½), and plasma clearance (Cl) of amobarbital were determined.
These results confirm those of Wilson, J.T. & Frohman, L.A. (J. Pharmacol. Exp. Ther. 189: 255, 1974) in the rat and suggest that GH may play an important role in developmental changes in drug metabolism.
(hGH was generously supplied by the National Pituitary Agency)
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Redmond, G., Bell, J. & Perel, J. ALTERATION OF HUMAN DRUG METABOLISM BY GROWTH HORMONE. Pediatr Res 11, 420 (1977). https://doi.org/10.1203/00006450-197704000-00305
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DOI: https://doi.org/10.1203/00006450-197704000-00305