Abstract
The purpose of this study was to measure changes in coronary flow and the extent of myocardial necrosis occurring after ventriculotomy in 5 control dogs and 7 dogs receiving mannitol (M). M was infused 1 hour before and 4 hours after vertical incision of the right ventricle. Coronary flow was measured with 9 micron microspheres (during anesthesia) before and 15 minutes after incision and (during wakefulness) at 4 and 24 hours after incision. At 48 hours the dogs were killed and the areas of necrosis measured by planimetry of photomicrographs. M increased serum osmolality from 282 ± 4 (SEM) to 331 ± 3 mOsm. In controls coronary flow (ml/min.100g) to myocardium within 1 cm of the incision fell from 61 ± 8 pre-cut to 40 ± 6 at 15 minutes, 43 ± 10 at 4 hours, and 45 ± 11 at 24 hours. Coronary flow to more distal myocardium did not fall significantly after incision. In M animals coronary flow to the incisional region fell from 71 ± 15 to 41 ± 5 at 15 minutes, 20 ± 3 at 4 hours and 28 ± 6 at 24 hours. Heart rates, cardiac outputs, right ventricular, and aortic pressures did not differ between M and control animals. Control dogs had necrosis involving 21.1 ± 3.7% of the right ventricular cross sectional area compared to 24.6 ± 2.8% in M dogs. Necrosis did not extend beyond 1 cm from the incision in control animals. These data indicate that infusion of M after ventriculotomy did not increase coronary flow and failed to reduce the extent of myocardial necrosis.
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Fixler, D., Buja, L., Wheeler, J. et al. INFLUENCE OF MANNITOL ON SALVAGING MYOCARDIUM DURING VENTRICULOTOMY. Pediatr Res 11, 390 (1977). https://doi.org/10.1203/00006450-197704000-00124
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DOI: https://doi.org/10.1203/00006450-197704000-00124