Abstract
The incidence of hyperlipidemia and the effect of dietary factors on serum lipid values were evaluated in 17 non-nephrotic patients with GFR < 60 ml/min/1.73 m2. The mean serum cholesterol level (C) in 17 children was 214 ± 50 mg/dl and the mean serum triglyceride level (TG) in 12 children was 187 ± 67 mg/dl. C was elevated (> 230 mg/dl) in 22% and TG (> 140 mg/dl) in 92% of the children. There was no correlation between lipid levels and GFR, albumin, creatinine or BUN.
Multiple computer diet analyses were obtained before and during nutritional supplementation. Absolute values for calories and grams of protein, carbohydrate (CHO), and fat increased. However, when expressed as a percentage of calories ingested, CHO increased 11% while fat decreased 8% and protein remained unchanged. In 16 patients C increased from 207 ± 38 mg/dl to 239 ± 49 mg/dl (p < 0.025) and in 10 patients TG increased from 197 ± 66 mg/dl to 215 mg/dl (p < 0.1). C and TG were not related to total calories, gm/kg CHO or % fat ingested. TG was related to % CHO of total calories ingested. Diet appears to be one of the factors influencing elevated lipid levels in uremic children.
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Arnold, W., Boosalis, M. & Holliday, M. SERUM LIPIDS IN UREMIC CHILDREN AND THE RESPONSE TO NUTRITIONAL SUPPLEMENTATION. Pediatr Res 11, 546 (1977). https://doi.org/10.1203/00006450-197704000-01057
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DOI: https://doi.org/10.1203/00006450-197704000-01057