Abstract
E1, E2, LH and FSH were measured radioimmunologically in 81 plasma specimens of 28 sexually precocious girls 1 to 10 years of age. Prior to treatment in these girls the mean E1 value (15 pg/ml) was within the infantile normal range, but the mean values of E2. (26 pg/ml), LH (1, 2 ng/ml) and FSH (1, 6 ng/ml) were significantly elevated. However, out of 63 plasmas only 31 showed elevated E2, 24 LH and 34 FSH values above the normal range for age. Grouping the values according to breast development revealed considerably lower estrogens and gonadotropins in patients than in normally maturating girls of the same developmental stage. During treatment with CY (mean daily dose: 50 mg/m2) the mean estrogen and gonadotropin levels of 8 patients decreased significantly (E1 : p<0.001; E2: p<0.01; LH: p<0.025; FSH: p<0.05). However, out of 18 plasmas from the girls treated 5 still had elevated E2, 6 LH and 12 FSH values in the pubertal range.
Supported by: DFG, SFB 51
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Bidlingmaier, F., Butenandt, O. & Knorr, D. PLASMA ESTERONE (E1) , ESTRADOL (E2) , LH AND FSH IN UNTREATED AND CYPROTERONACETATE (CY) TREATED GIRLS WITH PRECOCIOUS PUBERTY. Pediatr Res 9, 667 (1975). https://doi.org/10.1203/00006450-197508000-00016
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DOI: https://doi.org/10.1203/00006450-197508000-00016