Abstract
Plasma Cortisol levels were determined by C.P.B. before and after the I.M. administration of 0, 25 mgr. of AGTH (Nuvacthen in 22 children who had been previously admitted in our I.C.U. in severe shock from Meningococcal Septicemia. These values were compared with those of 23 normal children as controls. This test provides good discrimination between normal children and those with primary adrenal insuficiency. The increments in two cases of cronic primary adrenal insuficiency, in cortisol values were 0 and 1 ug % ml.
The mean values and S.D. of the cortisol basal levels found in children after recovery were 12,2 ug % ml. ± 4,6 and for the normal children 15,7 ug % ml.± 3,9. This difference is statisticaly significant ( Student's test ) ( P <0,02 ) The plasma cortisol values after 30' minutes ACTH administration showed 29,8 ug % ml.± 5,3 for normal children and 24,6 ug fa ml.± 5,1 for the children after recovered. This difference is statistioaly significant ( P < 0,01 ).
The increments in both groups were 14, 1 ug % ml.± 4,8; and 12, 3 ug % ml. ±4,3. There is not significant difference ( P > 0,1 ). It is established from this study that there are not differences in adrenal response between both groups as measured with this “ short test ”
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Potau, N., Vicens-Calvet, E., Sauleda, J. et al. EVALUATION OF THE ADRENAL RESPONSE AFTER ACTH STIMULATION IN CHILDREN WHO RECOVERD FROM SEVERE MENINGOCOCCAL SEPTICEMIA. Pediatr Res 9, 690 (1975). https://doi.org/10.1203/00006450-197508000-00137
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DOI: https://doi.org/10.1203/00006450-197508000-00137