Abstract
Plasma glucagon (IRG) and insulin (IRI) responses to intravenous infusion of arginine (A:0–60 min) plus glucose (A+G:30–60 min) were examined in 7 children with idiopathic short stature (SS), 6 with moderate obesity (ob), 7 with gross obesity (OB), and 3 juvenile diabetics (DB). Mean (±SE) plasma IRG (pg/ml) was highest in the OB group :
Similar fold (x2–3) increases of plasma IRG were seen for all groups during A, as well as similar decreases of IRG during A+G. IRI responses to A as well as A+G were smaller in the SS group. These data suggest that plasma glucagon responses are intact and may even be exaggerated in obesity.
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Schneider, P., Rabinovitch, A., Paunier, L. et al. ALPHA CELL FUNCTION IN SHORT, OBESE, AND DIABETIC CHILDREN. Pediatr Res 9, 674 (1975). https://doi.org/10.1203/00006450-197508000-00057
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DOI: https://doi.org/10.1203/00006450-197508000-00057