Abstract
Testis biopsy materialswere taken from 10 cryptorchid boys during maldescensus operation, whereas normal materials were obtained from deceased patients. 3H-Pregnenolone and l4C-progesterone were used as substrates. Biotransformation of both substrates to testosterone was found to be diminished markedly in the cryptorchid materials when related to the normals. The normal testis biotransformed pregnenolone in a more pronounced way to the 5α -reduced substances, such as dihydrotestosterone and androstanediol, than did the eryptorchid materials. Those differences were less evident using labelled progesterone as a substrate. Here, androsterone was a major metabolite and the yield for, the cryptorchid tissues was significantly greater than that for the normals.
In conclusion the cryptorchid testis showed marked differences in the pattern of biotransformation of the labelled steroid precursors.
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Rager, K., Grumbach, S., Attanasio, A. et al. IN VITRO-MICRO-BIOTRANSFORMATION OF PREGNENOLONE AND PROGESTERONE IN TESTIS BIOPSY MATERIAL OF CRYPTORCHID, BOYS. Pediatr Res 9, 673 (1975). https://doi.org/10.1203/00006450-197508000-00052
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DOI: https://doi.org/10.1203/00006450-197508000-00052