Abstract
The consequences of respiratory and metabolic acidosis are poorly documented. The consequences of over treatment are not well understood. The responses to metabolic and respiratory acidosis and alkalosis of the pulmonary and systemic vasculature were studied in anesthetized dogs measuring pulmonary and systemic B.P., C.O., R.A. and L. A. B.P. The following is a graphic summary of the measured changes during 15 min. of respiratory manipulation or 10 min. following an infusion of bicarbonate or acid:
The major change seen in respiratory alkalosis was a decrease in B.P. and in C. O. with an increase in pulmonary resistance. These are changes which should be avoided with the use of ventilatory assistance. There was an increase in both B.P. & C.O. with respiratory acidosis. The major change with metabolic alkalosis was an increase of C.O. and a decrease in systemic resistance which could be duplicated with the infusion of hypertonic saline. There were very few measurable changes following acid infusion. Caution should be used in the correction of metabolic acidosis.
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Eitzman, D., Garrison, R., Egan, E. et al. Effects of Metabolic and Respiratory Acidosis & Alkalosis. Pediatr Res 8, 467 (1974). https://doi.org/10.1203/00006450-197404000-00760
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DOI: https://doi.org/10.1203/00006450-197404000-00760