Abstract
Fetal plasma renin activity (PRA) is high when compared to the ewe. To study the effect of this high PRA on fetal renal function, (Sar1, Ile8)-Angiotensin II (A-II) inhibitor was infused into 5 fetal lambs. After measuring GFR, CPAH, filtration fraction (F.F.), urine flow (UV), Cosm, arterial pressure and renal vascular resistance for 3 control periods, A-II inhibitor was infused at 7 mgm/kg/min for 3 study periods. Two (2) recovery periods were then done.
Systolic pressure did not fall but there was a significant increase in P.P. Inhibition of A-II resulted in a significant fall in GFR, CPAH and UV while the F.F. increased. This effect persisted after discontinuing the infusion. These data suggest that elevated fetal PRA is an appropriate response to low total renal blood flow and that GFR, renal plasma flow and UV are significantly maintained by the high PRA.
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Moore, E., Paton, J., deLannoy, C. et al. EFFECT OF (Sar1, Ile8)-ANGIOTENSIN II INHIBITOR ON GLOMERULAR FILTRATION AND RENAL PLASMA FLOW IN THE FETAL LAMB. Pediatr Res 8, 459 (1974). https://doi.org/10.1203/00006450-197404000-00712
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DOI: https://doi.org/10.1203/00006450-197404000-00712