Abstract
During a 10 year period (1962-1972) 78 patients (1-13 years, 2,:1 male/female) with INS were treated with prednisone at a dose of 60 mg/M2/day for 21 days followed by intermittent therapy (M, T, W) for 1 year. Of the 61 responders, 64% had no relapse, 23% had 1 and 13% had>2 relapses. Biopsy was performed on 43 patients of which 65% were minimal change (nil.)
Initial therapy and response to prednisone are similar to data of the International Study (80% responders), however, with intermittent therapy the rate of those responding or relapsing frequently is significantly improved in comparison to that reported in the International Study. No clinically significant steroid toxicity was encountered. This study shows a reduced relapse rate in children responding to steroid therapy when an intermittent dosage is maintained for one year.
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Lutz, R., Shahin, B., Papadopoulou, Z. et al. LOWERED INCIDENCE OF RELAPSE IN IDIOPATHIC NEPHROTIC SYNDROME (INS) AFTER ONE YEAR OF INTERMITTENT PREDNISONE THERAPY. Pediatr Res 8, 458 (1974). https://doi.org/10.1203/00006450-197404000-00706
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DOI: https://doi.org/10.1203/00006450-197404000-00706