Abstract
Numerous cysts of the ovary in childhood have been reported but only rarely have these cysts been considered as a causative factor in sexual precocity(SP). A 16 mo. infant with SP was found to have a 4 × 5 cm cyst containing 1.6 ug/ml of 17-B estradiol(E2). This was felt to represent a functioning autonomous cyst(FAC) and was removed. Pre-op plasma E2-9.42 ng/ml and the E2 level in urine was 2.9 ug/24 hr with a post-op value of 0.28 ug/24 hr. Prior to surgery serum LH-0.24 mIu/ml and FSH-0.26 mIU/ml. There is no recurrence of SP 8 mo. after surgery. Another infant with McCune-Albright's syndrome (MAS) had SP and localized skin pigmentation at 7 mo. of age. Her mother had been on large doses of I.M. hydroxyprogesterone during the first half of pregnancy. A bone survey initially revealed no area of fibrous dysplasia. Pre-op serum LH-3.9 mIU/ml and FSH-2.2 mIu/ml. At operation a 2 cm lutein cyst (previously undescribed in MAS) was removed. SP recurred within six weeks after surgery. Subsequent bone survey at 11 mo. of age revealed 3 minimal areas of fibrous dysplasia. Conclusion: Oophorectomy is indicated only in patients with SP, ovarian cyst, elevated estradiol in plasma, relatively low plasma LH and FSH and apparent obliteration of ovarian stroma.
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Young, R., Dunn, L., Salzbeiq, A. et al. AUTONOMOUS AND SECONDARY CYSTS OF THE OVARY WITH SEXUAL PRECOCITY. Pediatr Res 8, 378 (1974). https://doi.org/10.1203/00006450-197404000-00227
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DOI: https://doi.org/10.1203/00006450-197404000-00227