Abstract
Water, electrolytes (Na,K,Cl,P) and intracellular proteins were determined on muscle sampled by needle biopsies in 50 chronic uremic children. Their creatinine clearance was below 30 ml/mn/l.73 m2 and seven patients were already in chronic haemodialysis. Total water was increased in all cases. The increase was due to an excess of ECW and ICW in moderate chronic renal failure, while at the terminal stage, only ECW was augmented. BP were positively correlated with ECW. Muscle sodium (Nam) content increased with the renal failure. ECW and Nam were in direct relation, however the Nam was increased less than the expansion of ECW. Muscle chloride, normal in many cases, was very high (>2 Cl−) in 9 terminal cases. Intracellular K+ was increased in half of the patients especially dialysed and terminal uremic patients. Total phosphorus was slightly increased only in terminal renal failure. These modifications in muscle electrolytes cannot be assumed by their plasma values. Total intracellular proteins were below the normal range in more than half the cases. These results suggest that there is a correlation between alteration of renal functions and changes in muscle milieu. However these disturbances appear obvious only when renal function is really reduced (cl. creat. < 5 ml/mn/1.73 m2).
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Delaporte, C., Broyer, M. & Royer, P. Modifications in fluid compartments, electrolytes and intracellular proteins of muscle in uremic children. Pediatr Res 8, 913 (1974). https://doi.org/10.1203/00006450-197411000-00089
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DOI: https://doi.org/10.1203/00006450-197411000-00089