Abstract
Standard technique for H ion balances were carried out in 6 infants on TPN. Balance periods varied between 4 and 7 days. Blood chemistry and acid-base parameters remained in normal limits during the study period. The mean body input of H ions (1.05 mEq/kg/24 h.) was balanced with the mean net acid excretion (1.16 mEq/kg/24 h.) and S04 excretion was correlated with N retention. The comparison of our results with the ones obtained in infants on enteral nutrition by other authors revealed that TPN increases the mean urinary organic acid excretion by nearly × 3.5 and that of S04 by nearly × 6. But quantitatively urinary organic acid constituted the most important fraction of endogenous acid production (4.95 mEq/kg/24 h) and it was balanced wi^h the metabolisable non measured anions in the perfusion (5.46 mEq/kg/24h). It is concluded that an adequate daily nitrogen and calorie intake (400 mg N/kg/24 h and 100 cal/gk/24 h respectively) the use of a well-balanced mixture of cathionic and anionic aminoacids (Vamin) and the intravenous supply of metabolisable non measured anions to compensate the endogenous organic acid production played the most important rôle in the satisfactory H ion balance of our infants.
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Broyer, M., Hatemi, N., Dechaux, M. et al. Balance of H ions in infants on TPN. Pediatr Res 8, 903 (1974). https://doi.org/10.1203/00006450-197411000-00046
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DOI: https://doi.org/10.1203/00006450-197411000-00046