Abstract
Extract: Haemophilus influenzae type b antibodies were measured quantitatively in normal and immunized humans and in commercially available pooled immunoglobulin. A “protective” serum level was estimated to be 0.06 to 0.1 $mUg antibody/ml based upon the anti-type b concentration in normal adult sera and pooled immunoglobulin. An age-related difference characterized the adult and infant serum antibody response to injection of the purified type b capsular polysaccharide. The adults responded with higher and sustained antibody levels than the infants and children. An immunized infant reacted with type b antibody formation after nasopharyngeal carriage of H. influenzae type b and two infants reacted with type b antibodies after enteric carriage of Escherichia coli with a cross-reacting antigen.
Speculation: Qualitative and quantitative differences characterize the adult versus the infant re-response to the capsular polysaccharide of H. influenzae type b. This age-related difference in the serum anti-type b antibody response may be due to the development of differentiated cells induced by whole bacteria, either as H. influenzae type b or by other organisms with cross-reacting antigens. The “protective” level of serum anti-type b antibodies, estimated by two methods, was achieved by immunization of infants, which suggests that this procedure may confer protective immunity.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Robbins, J., Parke, J., Schneerson, R. et al. Quantitative Measurement of “Natural” and Immunization-induced Haemophilus influenzas type b Capsular Polysaccharide Antibodies. Pediatr Res 7, 103–110 (1973). https://doi.org/10.1203/00006450-197303000-00001
Issue Date:
DOI: https://doi.org/10.1203/00006450-197303000-00001
Keywords
This article is cited by
-
Meningococcal Groups C and Y and Haemophilus b Tetanus Toxoid Conjugate Vaccine (HibMenCY-TT; MenHibrix®): A Review
Drugs (2013)
-
Maintaining protection against invasive bacteria with protein–polysaccharide conjugate vaccines
Nature Reviews Immunology (2009)
-
Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations
Springer Seminars in Immunopathology (2001)
-
Haemophilus influenzae Type b Conjugate and Combination Vaccines
Clinical Immunotherapeutics (1995)
-
Immunogenicity ofHaemophilus influenzae type b capsular polysaccharide and its tetanus toxoid conjugate in patients with recurrent infections or humoral immunodeficiency
International Journal of Clinical & Laboratory Research (1992)