Abstract
The high content of a alkaline phosphatase (AP) of the gunica pig thymocytes offers a simple endogenous lable for these cells. AP can be easily demonstrated in historical sections and smears of cells. The lymphocytes of the guniea pig blood are mostly AP-negative, only every 1/1000 white cell being an AP. positive lymphocyte. When given intravenously, the thymocytes very rapidly disapper from blood. They are then seen in the spleen, lymph nodes, bone marrow, and liver. Most of the hymphocytes in these peripheral lymphoid organs are AP-negative under normal conditions. The results indicate that either relatively few thymocytes leave the thymus or, if they leave in large amounts, they are rapidly destroyed and few reside longer in the peripheral lymphoid organs.
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Kouvalainen, K., Ruuskanen, O. 55. Kinetics of thymocytcs. Pediatr Res 5, 95 (1971). https://doi.org/10.1203/00006450-197102000-00060
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DOI: https://doi.org/10.1203/00006450-197102000-00060