Abstract
The indirect immunfluorescence technique was applied to test vital leukemic cells (blasts from peripheral blood and bone marrow) for the existence of tumor-specific transplanatation antigens on their membranes. The studies were carried out in hoologous as in autologons systems. Sera gathered from leukemic children in different phases of the disease were tested for antibodies against autologous blasts in times of relapse and against homologous blasts. The sera of adult contact persons were tested for antibodies against the cells of childhood leukemia using parablasts. Antibodies were found in 11 out of 28 tested sera (11 28), monocytoid blasts (5 21), and paramycloblasts (1 10). In relapse autoantibodies against parablasts could not be found (4 children). These are preliminary results of studies going on at the time of print.
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Plenert, W., Zintl, F. & Aurich, G. 26. Studies on tumor-specilie transplantation antigens in childhood leukemia. Leukemia. Pediatr Res 5, 88 (1971). https://doi.org/10.1203/00006450-197102000-00031
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DOI: https://doi.org/10.1203/00006450-197102000-00031