Abstract
Placental alkaline phosphatase presents electrophoretic polymorphism with 6 common phenotypes determined by 3 alleles (Pls1, Plf1 and Plf1) at an autosomal locus. The electrophoretic pheonotypes of alkaline phosphatase from 2000 consecutively delivered placentas of white and negro subjects were determined. The results were subdivided according to race and to the presence or absence of Rh and/or ABO feto-maternal incompatibility. In the group of ABO incompatible infants, a further subdivision was made according to the presence or absence of a positive direct Coombs test and/or jaundice. Within the compatible groups the frequency of allele Pls1 was significantly higher in “first born” than in “subsequently born” infants. The reverse was true in the incompatible groups. Among infants with ABO incompatibility, allele Pf1 was significantly more frequent in infants without evidence of isoimmunization than in those with a positive Coombs test and/or jaundice. These results suggests that placental alkaline phosphatase may play a role in the maintenance of the fertilized ovum in utero and that in this regard allele Pls1 may be more efficient than allele Plf1. These results also suggest the possibility of an interaction between the polymorphism of placental alkaline phosphatase and those of Rh and ABO systems whereby, in the presence of feto-maternal incompatibility, allel Plf1 seems to provide an advantage when compared to allele Pls1.
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Bottini, E., Lucarelli, P., Plgram, P. et al. Evidence of interaction between the polymorphism of placental alkaline phosphatase and those ofRh and Abo systems. Pediatr Res 5, 423 (1971). https://doi.org/10.1203/00006450-197108000-00216
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DOI: https://doi.org/10.1203/00006450-197108000-00216