Abstract
Embryonal rhabdomyosarcoma, when inoperable or metastatic, has usually ben a rapidly fatal cancer. Intensive combination chemotherapy (VAC) with Vincristine (VCR), Actinomycin-D (AMD) and Cyclophosphamide (CYT) in conjunction with radiotherapy is effective in the treatement of this tumor. Twenty-one children with inoperable or metastatic embryonal rhabdomyosarcoma, or undifferentiated sarcoma suggestive of embryonal rhabdomyosarcoma, were treated in the 3-year period 1967–1969. Sixteen of them (76%) are alive without evidence of disease 1–4 years after initiation of therapy. Therapy consisted of biopsy, Co80 radiation 5000–6000 rads tumor dose, and VAC chemotherapy. Surgery was subsequent;ly utilized when feasible. The chemotherapy consisted of VCR 2 mg./M2 IV weekly x12, AMD 75 MG./kG. divided into 5–8 daily doses every 3 months for 5 or 6 courses, and CYT given either as 2.5 mg./Kg./day for 2 years or 10 mg./Kg./day for 7 days every 6 weeks. The type of CYT therapy was dependent on tumour location and extent.
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Wilbur, J., Sutow, W., Sullivan, M. et al. Successful treatment of inoperable embryonal rhabdomyosarcoma. Pediatr Res 5, 408 (1971). https://doi.org/10.1203/00006450-197108000-00154
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DOI: https://doi.org/10.1203/00006450-197108000-00154