Abstract
Three infants presented around I year of age with failure to thrive, comiting, and anorexia and were shown to have severe jejunal mucosal lesions characteristic of celiac disease before or at the time of onset of mild diarrhea. Two infants had fecal retention, none had steatorrhea, and all have thrived on glutenfree, milk-containing diets. Other investigations were confirmatory, including some sugar tolerance tests, and assays of mucosal lactase, glutamyl-tyrosine, γ-glutamyl-β-napthylamide, and glycylleucine; the dipeptidase assays were by a zymographic technique. Immunoglobulins were measured by single radial diffusion and showed high IgA in each child, low IgM in one, and variable IgG levels. The mucosal lesion of gluten-induced celiac disease can be demonstrated before diarrhea or steatorrhea occur.
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McNicholl, B., Mitchell, B. 7. Celiac disease sans diarrhea. Pediatr Res 5, 84 (1971). https://doi.org/10.1203/00006450-197102000-00012
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DOI: https://doi.org/10.1203/00006450-197102000-00012