Abstract
Selectivity of proteinuria as measured by clearance ratios of transferrin and IgG were performed in 28 children with nephrotic syndrome. Selectivity correlated with response to steroid therapy, histology when available (16 patients) and was not related to degree of proteinuria or altered by therapy.
Radial diffusion methods (Mancini) using commercially prepared plates and values using the Ouchterlony method gave comparable results which remained constant, within the limits of the method throughout repeated testing.
Critical evaluation of results shows that high protein excretion is necessary for accurate prediction of steroid response. Preliminary studies suggest that calculation of selectivity is possible even at low levels of protein excretion by comparison of clearance of transferrin, IgG and α2 macroglobulin performed on urine, in which the protein has been concentrated by lyophylization.
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Herrin, J., Saltzman, A. & Crawford, J. Correlations of selectivity of protein excretion in childhood nephrotic syndrome. Pediatr Res 5, 383 (1971). https://doi.org/10.1203/00006450-197108000-00052
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DOI: https://doi.org/10.1203/00006450-197108000-00052