Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Functional Studies of Toung Versus Old Platelets in a Patient with Chronic Thrombocytopenia

Abstract

The reprdoucible platelet production cycle following infusion of fresh frozen plasma (FFP) in a girl with chronic thrombocytopenia [Blood 16: 943, 1960] provided a unique opportunity to study the functional capacity of young and old platelets. Study cycles were initiated by infusing FFP when the patient's platelet count was less than 20,000/mm3. ‘Young’ platelet studies were done 4 days after FFP when the patient's platelet count was less than 20,000/mm3); ‘old’ platelet studies were done 21 days after FFP (average platelet count, 200,000/mm3). All studies were repeated during several such cycles. In association with a young platelet population, were normal Ivy bleeding times, normal or increased platelet adhesiveness, normal aggregation to ADP and collagen, and normal platelet factor 3 availability (PF-3a). By contrast, when the patient's circulating platelets were old, she was found to have long bleeding times, abnormally low adhesiveness in vivo and in vitro, and decreased PF-3a. Aggregation to ADP and collgen was slightly decreased but remained within normal limits. No abnormalities were seen by electron microscopy on platelet samples obtained throughout the cycle. (Performed by Dr. JAMES WHITE, Univ. of Minn.) It is of interest that on several occasions the patient experienced mild bleeding manifestations at the end of a cycle but while her platelet count was still normal. These episodes correlated with the findings of long bleeding time and decreased adhesiveness.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Johnson, C., Abildgaard, C. & Schulman, I. Functional Studies of Toung Versus Old Platelets in a Patient with Chronic Thrombocytopenia. Pediatr Res 4, 464–465 (1970). https://doi.org/10.1203/00006450-197009000-00122

Download citation

Search

Quick links