Abstract
Hyperexcretion of urinary phosphorus, and free amino acids, resulting from diminished net tubular absorption, occurred in rats fed for 6 weeks or more, from weaning, on low calcium diets (0.02 %) and normal phosphorus intakes. The intensity of renal dysfunction was proportional to the degree of hypocalcemia below 6.5 mg%; the Vitamin D content of the diet was immaterial to the relationship; controls pairfed on 0.4 % calcium diets did not develop renal dysfunction. Intrapetitoneal calcium injected and parathyroidectomy suppressed the urinary hyperexcretion of amino acids and phosphorus; injection of parathyroid extract (LILLY) enhanced it. Rickets and bound hyperaminoaciduria also occurred in hypocalcemic animals; hydroxyproline, proline and glycine were particularly prominent in the bound fraction. Parathyroid glands showed increased mitoses and cellular hypertrophy, proportional to the severity of hypocalcemia, and irrespective of Vitamin D intake. The data imply that excess circulating parathyroid hormone, rather than Vitamin D deficiency itself, accounts for the bound aminoaciduria and impaired membrane transport of amino acids and.phosphorus in Vitamin D deficiency. (Supported by M.R.C. Grant, MT-1085, and N.I.H. Grant, AM-05117) (SPR)
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Grose, J., Scriver, C. & Fawcett, J. 74 Hyperexcretion of Urinary Amino Acids and Phosphorus in the Vitamin D-Deficient Holtzman Rat. Pediatr Res 1, 219 (1967). https://doi.org/10.1203/00006450-196705000-00081
Issue Date:
DOI: https://doi.org/10.1203/00006450-196705000-00081