Abstract
Renal hypertrophy is a known response to metabolic acidosis produced by ammonium chloride loading in rats (LOTSPEICH : Amer. J. Physiol. [1965]). The hypertrophic response and functional correlates in this model were studied and compared with those following uninephrectomy in 4 groups of rats: 1. controls; 2. NH4Cl loaded; 3.uninephrectomized controls; 4.uninephrectomized NH4Cl loaded. Glomerular filtration rates (GFR), glucose tubular maxima (TmG), wet kidney weights (WKW), and kidney DNA were determined.
Hypertrophy occurred with NH4Cl loading and was additive to that following uninephrectomy. Elevation of DNA levels indicated hyperplasia as well as hypertrophy in both models. As a function of kidney weight however, both GFR and TmG decreased in the NH4Cl fed animals. Microscopic examination revealed no architectural difference in the 2 types of hypertrophy. The data indicate that stimulated growth of the kidney is not necessarily associated with an increase in function as is normal growth. These data together with the data from other models of kidney growth provide a basis for searching for the structural or enzymatic determinant of kidney function as measured by sodium reabsorption and maximal glucosereabsorption. (SPR)
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Potter, D., Sakai, T. & Holliday, M. 47 Renal Hypertrophy with Diminished Function in Acidotic Rats. Pediatr Res 1, 212 (1967). https://doi.org/10.1203/00006450-196705000-00054
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DOI: https://doi.org/10.1203/00006450-196705000-00054