Abstract
Chiral lipids (quarternized form) were synthesized from L-,D.-, racemic alanine, L-phenyl alanine and L-glutamic acid having C10 alcohol unit as an ester group and DNA hybrid complexes were prepared from these chiral lipids. The as-cast DNA-L-alanineC10 complex film showed a self-assembled structure which was enhanced by water, while no self assembled structure was observed for the DNA-D-or racemic alanine C10 complex film. DNA-L-Glutamic acidC10 (GluC10) lipid and L-phenylalanineC10 (PhAlC10) lipid complexes did not form a self-assembled structure which was clearly observed for the DNA-L-alanineC10 complex. Two C10 alkyl groups of GluC10 and bulky benzyl group of PhAlC10 surrounding DNA double helix may disturb the formation of the self-assembled structure.
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Ogata, N., Yamaoka, K. DNA–Lipid Hybrid Films Derived from Chiral Lipids. Polym J 40, 186–191 (2008). https://doi.org/10.1295/polymj.PJ2007010
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DOI: https://doi.org/10.1295/polymj.PJ2007010