Abstract
It was first found that there is good correlation between saturation transfer ratio (STR) values in magnetic resonance imaging (MRI) measurement and the hydrophilicity of various synthetic copolymer gels containing 2-hydroxyethyl methacrylate (HEMA), glycidryl methacrylate (GMA), N-vinyl-2-pyrrolidinone (N-VP), and/or methyl methacrylate (MMA). The hydrophilicity of these copolymer gels was characterized by water contents evaluated by differential scanning calorimeter (DSC) and also the solubility parameter in theoretical sense. The MRI measurement was performed by conventional field-echo imaging as well as under the irradiation of an off-resonance saturation pulse apart by 75, 19, and 4ppm from a resonance point of water. The STR values offset at the 75-ppm correlated well with the total water contents in the samples. The values offset at the 19-ppm divided the samples into two classes corresponding to hydrophilic and hydrophobic gels. In the case of 4-ppm offset, the hydrophilic gels showed significantly higher STR values than the hydrophobic ones and the values among the hydrophilic gels were reflective to the constrained water content in the gel. Moreover the values correlated linearly with the solubility parameter of the samples. Thus the STR values in measurement of MRI could be adopted as a new useful parameter for molecular or material characterization of synthetic copolymers without any invasive processes.
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Matsushima, S., Takasu, A., Inai, Y. et al. Saturation Transfer Ratio in Magnetic Resonance Imaging. A Novel Physical Parameter for Evaluation of the Hydrophilicity of Synthetic Copolymer Gels. Polym J 32, 828–833 (2000). https://doi.org/10.1295/polymj.32.828
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DOI: https://doi.org/10.1295/polymj.32.828