Abstract
The direct polycondensation of racemic lactic acid using condensing agents, such as 1,1′-carbonyldiimidazole (CDI), N,N,N′,N′-tetramethylchloroformamidinium chloride (TMCFAC), and N,N′-dicyclohexylcarbodiimide/4-dimethylaminopyridine (DCC/DMAP), was investigated. Reactions using CDI proceeded slightly. Polycondensation using TMCFAC with pyridine gave a polymer in 83% yield, but the number-average molecular weight (M̄n) was 3700. Thus, TMCFAC is not effective in the direct polycondensation of lactic acid. However, DCC/DMAP is effective, and polycondensation in dichloromethane at room temperature for 24 h afforded poly(lactic acid) having M̄n of 15400 in 89% yield.
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Akutsu, F., Inoki, M., Uei, H. et al. Synthesis of Poly(lactic acid) by Direct Polycondensation of Lactic Acid Using 1,1′-Carbonyldiimidazole, N,N,N′,N′-Tetramethylchloroformamidinium Chloride, and N,N′-Dicyclohexylcarbodiimide as Condensing Agents. Polym J 30, 421–423 (1998). https://doi.org/10.1295/polymj.30.421
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DOI: https://doi.org/10.1295/polymj.30.421