Abstract
The reactions employed for coupling anti-platelet and other drugs to hydroxylic polymers are described. The drugs include the prostaglandin analogue 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW 245C) and the phosphodiesterase inhibitors dipyridamole and theophylline. Polymers studied were poly(vinyl alcohol), dextran, and poly(ethylene glycol), and coupling was effected either with the aid of halo-isocyanates or by a two-stage process using carbonyl diimidazole. These novel reaction sequences appear to have wide applications. Some data are presented on the inhibition of platelet aggregation by the free and coupled drugs.
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Bamford, C., Middleton, I., Al-Lamee, K. et al. Routes to Bioactive Hydrophilic Polymers. Polym J 19, 475–483 (1987). https://doi.org/10.1295/polymj.19.475
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DOI: https://doi.org/10.1295/polymj.19.475
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