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Routes to Bioactive Hydrophilic Polymers

Polymer Journal volume 19, pages 475483 (1987) | Download Citation

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Abstract

The reactions employed for coupling anti-platelet and other drugs to hydroxylic polymers are described. The drugs include the prostaglandin analogue 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW 245C) and the phosphodiesterase inhibitors dipyridamole and theophylline. Polymers studied were poly(vinyl alcohol), dextran, and poly(ethylene glycol), and coupling was effected either with the aid of halo-isocyanates or by a two-stage process using carbonyl diimidazole. These novel reaction sequences appear to have wide applications. Some data are presented on the inhibition of platelet aggregation by the free and coupled drugs.

References

  1. 1.

    and , Eur. Polym. J., 19, 1027 (1983).

  2. 2.

    and , “Plenary and Invited Lectures,” Macro 83, Bucharest, Rumania, p 168.

  3. 3.

    , , and , Polymer, 26, 945 (1985).

  4. 4.

    C. H. Bamford, I. P. Middleton, and K. G. Al-Lamee, Biochim. Biophys. Acta, in course of publication.

  5. 5.

    , , , and , “Advances in Polymer Synthesis,” B. M. Culbertson and J. E. McGrath, Ed., Plenum Press Publishers, New York, 1985, p 291.

  6. 6.

    , , and , Polymer, 27, 1981 (1986).

  7. 7.

    , , and , Biochim. Biophys. Acta, 886, 109 (1986).

  8. 8.

    , “New Trends in the Photochemistry of Polymers,” N. S. Allen and J. F. Rabek Ed., Elsevier Applied Science Publishers, London, 1985, p 125.

  9. 9.

    , , , and , in “Blood Compatible Materials and their Testing,” S. Dawids and A. Bantjes, Ed., Martinus Nyhoff Publishers, Dordrecht, Netherlands, 1986, p 159.

  10. 10.

    and , J. Am. Chem. Soc., 87, 5661 (1965).

  11. 11.

    and , J. Am. Chem. Soc., 88, 1762 (1966).

  12. 12.

    , , , and , “Macromolecular Preprints,” Macromolecules 86 Conference, Oxford, p 81.

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  1. Institute of Medical and Dental Bioengineering, University of Liverpool

    • Clement Bamford
    • , Ian Middleton
    • , Kadem Al-Lamee
    • , Jerzy Paprotny
    •  & Yoshikatsu Satake

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DOI

https://doi.org/10.1295/polymj.19.475