Abstract
Polymerization of γ-benzyl N-carboxy-l-glutamate anhydride was initiated by the primary amino groups capped at both ends of poly(ethylene oxide) as the middle block component. Before the preparation, the terminal hydroxyl groups of the middle block were reacted with excess tosylchloride. Subsequent treatment of tosylated poly(ethylene oxide) with potassium phthalimide and refluxing of the resulting product with hydrazine hydrate afforded the primary amine-terminated poly(ethylene oxide). From the data of infrared spectroscopy, it was found that the polypeptide chain block in A-B-A type block copolymers obtained exists in the α-helical conformation in the same manner as poly(γ-benzyl l-glutamate). Furthermore, it has been suggested by the circular dichroism measurements in the solid state that the helical content of the polypeptide block chain decreases gradually by swelling in water depending on the treatment time and the molar amount of poly(ethylene oxide).
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Kugo, K., Ohji, A., Uno, T. et al. Synthesis and Conformations of A-B-A Tri-Block Copolymers with Hydrophobic Poly(γ-benzyl l-glutamate) and Hydrophilic Poly(ethylene oxide). Polym J 19, 375–381 (1987). https://doi.org/10.1295/polymj.19.375
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DOI: https://doi.org/10.1295/polymj.19.375
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