Abstract
An attempt was made to evaluate certain pharmacodynamic properties of sodium cellulose sulfate (NaCS) using rats, rabbits, dogs, and cats. Two NaCS samples, whose molecular characteristics, anticoagulant activity and acute toxicity were determined in our previous paper [Polym. J., 15, 309 (1983)], were used. A pyrogen test was made, and the changes in blood pressure, heart rate and respiration, and the effect of histamine antagonists pre-treatment were examined. The following was confirmed: 1) An intravenous administration of 1 mg kg−1 of the two NaCS to dogs and cats had no effect on the cardiac function of these animals. 2) At a dose level of 10 mg kg−1 of the two NaCS to dogs, an abrupt blood pressure depression amounting to 40—100 mmHg in the average blood pressure was observed, and found to be proportional to the reciprocal of the acute toxicity (LD50). This finding indicated that the blood pressure depression by NaCS administration is dependent on the molecular weight and the distribution of the substituent (‹‹f2››+‹‹f3››) NaCS. 3) NaCS administration to a cat induced an abrupt rise in blood pressure, in contrast to the case of the dog. 4) NaCS administration was accompanied by tachyphylaxis. 5) The liberation of histamine and acetylcholine as the cause of these cardiac changes by NaCS administration was ruled out experimentally, and the liberation of bradykinin was considered the most probable cause.
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Kamide, K., Okajima, K., Matsui, T. et al. Pharmacodynamic Properties of Sodium Cellulose Sulfate. Polym J 16, 259–265 (1984). https://doi.org/10.1295/polymj.16.259
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DOI: https://doi.org/10.1295/polymj.16.259