Abstract
Proton NMR spectra of cyclic hexapeptides, cyclo(L-Ser(O-Bzl)-D-Leu-L-His)2 and cyclo(L-Ser-D-Leu-L-His)2, were measured and analyzed to study their solution conformation. The histidyl imidazolyl planes were found to have a tendency to face predominantly toward the adjacent D-leucyl side chains. It was also confirmed that the cyclic peptides are very likely to have Type II′ β-turns in the D-Leu-L-His sequence.
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Kodaka, M., Shimizu, T. & Hatano, M. Conformation of Cyclo(L-Ser(O-Bzl)-D-Leu-L-His)2 and Cyclo(L-Ser-D-Leu-L-His)2 in Solution. Polym J 16, 217–222 (1984). https://doi.org/10.1295/polymj.16.217
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DOI: https://doi.org/10.1295/polymj.16.217