Abstract
The heats of mixing for an equimolar mixture of poly(inosinic acid) (poly(I)) and poly(citidylic acid) (poly(C)) in solutions of various NaCl concentrations were measured by using the microcalorimeter of LKB batch type at 298±0.002 K. In a dilute NaCl solution, an equimolar mixture of poly(I) and poly(C) forms a poly(I)·poly(C) duplex(I) with double-stranded helical structure and its heat of interaction was estimated to be about −21 kJ per mole of base pair. On the other hand, when an NaCl concentration is more than 0.1 mol dm−3, an equimolar mixture of poly(I) and poly(C) also forms a poly(I)·poly(C) duplex(II) although poly(I) exists as an ordered structure such as a triple- or quadruple-stranded structure with an increase of the NaCl concentration, and its heat of interaction was estimated to be about −22 kJ per mole of base pair.
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Fujioka, K., Baba, Y., Kagemoto, A. et al. Interaction of Polynucleotides in Aqueous NaCl Solution (II): Poly(I)–Poly(C) System. Polym J 12, 843–847 (1980). https://doi.org/10.1295/polymj.12.843
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DOI: https://doi.org/10.1295/polymj.12.843