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Basic Research

Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate

Prostate Cancer and Prostatic Diseases volume 13, pages 65–70 (2010)Cite this article

Abstract

The purpose of this study is to report our method in detecting prostate cancer (PCa) using an 18-core transrectal ultrasound (TRUS) prostate biopsy (PB) schema, in combination with additional targeted cores from suspicious images in conventional (e-cMRI) and functional (e-fMRI) endorectal magnetic resonance imaging (e-MRI) of the prostate. From 2004 to 2008, 260 consecutive patients with a clinical suspicion of PCa underwent PB and were prospectively studied. e-cMRI and e-fMRI was performed in all patients before PB. The patients were divided into two groups (A and B) according to the results of their radiological findings (group A=suspicious findings, group B=non-suspicious findings). After the images were processed, an 18-core TRUS-guided PB was performed. When a patient exhibited a suspicious site on e-cMRI and e-fMRI images, three additional targeted PBs were obtained from that site. In group A, 17.5% of PCa was detected by the 18-core PB and 56.5% of PCa was detected by the targeted cores. The overall PCa detection rate (18+targeted cores) was 73.9%. The overall specificity was 73.9%. In group B, overall false-positive detection rate reached 19.2%, with the overall sensitivity being 80.8%. The method described above is not only practical but also a promising modality in PCa detection. As seen, PCa was optimally detected when combining the 18-core and targeted-core PB schema together. Non-suspicious images do not rule out the probability of PCa, thus justifying a PB in these patients as well.

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Acknowledgements

Parts of this study have been obtained with the permission of Mr Sami Takriti from his doctoral thesis.

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Author notes

  1. A P Labanaris and K Engelhard: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Martha Maria Medical Center, Academic Hospital of Erlangen University, Nuremberg, Germany

    A P Labanaris, R Nützel & R Kühn

  2. Department of Radiology, Martha Maria Medical Center, Academic Hospital of Erlangen University, Nuremberg, Germany

    K Engelhard

  3. Department of Urology, St Antonius Hospital, Gronau, Germany

    V Zugor

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  1. A P Labanaris
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  2. K Engelhard
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Correspondence to A P Labanaris.

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Labanaris, A., Engelhard, K., Zugor, V. et al. Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate. Prostate Cancer Prostatic Dis 13, 65–70 (2010). https://doi.org/10.1038/pcan.2009.41

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