Abstract
In this issue of Oncogene, Albinet et al. have demonstrated a critical role of melanoma sphingosine kinase 1, which catalyses formation of sphingosine 1-phosphate (S1P), in promoting the differentiation of fibroblasts into myofibroblasts. The myofibroblast sphingosine kinase 1 then promotes the S1P-dependent dissemination (metastasis) of melanoma cells via a S1P receptor 3-mediated mechanism. These findings are of major significance because they provide a novel mechanism of interaction between melanoma and the microenvironment niche in promoting metastasis. These studies therefore identify S1P derived from myofibroblasts and melanoma cells as a novel target for therapeutic intervention.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pyne NJ, Pyne S . Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010; 10: 489–503.
Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM et al. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med 2012; 4: 761–775.
Albinet V, Bats M-L, Huwiler H, Rochaix P, Chevreau C, Ségui B et al. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cell. Oncogene (doi:10.1038/onc.2013.303.
Li C, Zheng S, You H, Liu X, Lin M, Yang L et al. Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol 2011; 54: 1205–1213.
Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S et al. Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1. Am J Respir Cell Mol Biol 2007; 37: 395–404.
Gellings Lowe N, Swaney JS, Moreno KM, Sabbadini RA . Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. Cardiovasc Res 2009; 82: 303–312.
Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006; 9: 225–238.
Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C et al. S1PR1-STAT3 signalling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012; 21: 642–654.
Long JS, Edwards J, Watson C, Tovey S, Mair K, Schiff R et al. Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor positive breast cancer cells. Mol Cell Biol 2010; 30: 3827–3841.
Pyne S, Bittman R, Pyne NJ . Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. Cancer Res 2011; 71: 6576–6582.
Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 2013; 23: 107–120.
Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J 2012; 444: 79–88.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Pyne, N., Pyne, S. Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis. Oncogene 33, 3361–3363 (2014). https://doi.org/10.1038/onc.2013.292
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/onc.2013.292
This article is cited by
-
Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy
Inflammation Research (2017)