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TGFβ signaling in head and neck squamous cell carcinoma

Oncogene volume 29, pages 5437–5446 (2010)Cite this article

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Abstract

Transforming growth factor beta (TGFβ) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFβ signaling maintains epithelial homeostasis, dysregulated TGFβ signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGFβ signaling in epithelial cells causes hyperproliferation, reduced apoptosis and increased genomic instability, and the compensatory increase in TGFβ production by tumor epithelial cells with TGFβ signaling defects further promotes tumor growth and metastases by increasing angiogenesis and inflammation in tumor stromal cells. Here, we review the mouse models that we used to study TGFβ signaling in HNSCC.

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Acknowledgements

We thank our laboratory members for their contributions and Pamela Garl for proofreading. Work from the Wang laboratory was supported by NIH grants CA87849, CA79998, DE15953 and CA131483.

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  1. Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR, USA

    R A White

  2. Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, USA

    S P Malkoski

  3. Department of Pathology, University of Colorado Denver, Aurora, CO, USA

    X-J Wang

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White, R., Malkoski, S. & Wang, XJ. TGFβ signaling in head and neck squamous cell carcinoma. Oncogene 29, 5437–5446 (2010). https://doi.org/10.1038/onc.2010.306

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