News & Views | Published:

Three-dimensional intricacies in protein-DNA recognition and transcriptional control

Nature Structural & Molecular Biology volume 14, pages 11181119 (2007) | Download Citation

Transcription factors 'recognize' relatively short DNA consensus sequences; their full specificity must depend on a broader set of protein-protein and protein-DNA interactions. Joshi et al. show that, in addition to forming base pair–specific hydrogen bonds in the DNA major groove, certain Hox proteins detect DNA shape in the minor groove.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Nat. Rev. Genet. 6, 893–904 (2005).

  2. 2.

    et al. Cell 131, 530–543 (2007).

  3. 3.

    et al. Cell 59, 573–580 (1989).

  4. 4.

    , , , & Cell 63, 579–590 (1990).

  5. 5.

    et al. Cell 78, 211–223 (1994).

  6. 6.

    , , & Science 270, 262–269 (1995).

  7. 7.

    , , , & Nature 397, 714–719 (1999).

  8. 8.

    , , , & Cell 96, 587–597 (1999).

  9. 9.

    , , , & Science 242, 899–907 (1988).

  10. 10.

    , & Cell 129, 1111–1123 (2007).

Download references

Author information

Affiliations

  1. Stephen C. Harrison is in the Departments of Biological Chemistry and Molecular Pharmacology and of Pediatrics, Harvard Medical School, and is an investigator of the Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA. harrison@crystal.harvard.edu

    • Stephen C Harrison

Authors

  1. Search for Stephen C Harrison in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsmb1207-1118

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing