Transcription factors 'recognize' relatively short DNA consensus sequences; their full specificity must depend on a broader set of protein-protein and protein-DNA interactions. Joshi et al. show that, in addition to forming base pair–specific hydrogen bonds in the DNA major groove, certain Hox proteins detect DNA shape in the minor groove.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pearson, J.C., Lemons, D. & McGinnis, W. Nat. Rev. Genet. 6, 893–904 (2005).
Joshi, R. et al. Cell 131, 530–543 (2007).
Qian, Y.Q. et al. Cell 59, 573–580 (1989).
Kissinger, C.R., Liu, B.S., Martin-Blanco, E., Kornberg, T.B. & Pabo, C.O. Cell 63, 579–590 (1990).
Gehring, W.J. et al. Cell 78, 211–223 (1994).
Li, T., Stark, M.R., Johnson, A.D. & Wolberger, C. Science 270, 262–269 (1995).
Passner, J.M., Ryoo, H.D., Shen, L., Mann, R.S. & Aggarwal, A.K. Nature 397, 714–719 (1999).
Piper, D.E., Batchelor, A.H., Chang, C.P., Cleary, M.L. & Wolberger, C. Cell 96, 587–597 (1999).
Aggarwal, A.K., Rodgers, D.W., Drottar, M., Ptashne, M. & Harrison, S.C. Science 242, 899–907 (1988).
Panne, D., Maniatis, T. & Harrison, S.C. Cell 129, 1111–1123 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Harrison, S. Three-dimensional intricacies in protein-DNA recognition and transcriptional control. Nat Struct Mol Biol 14, 1118–1119 (2007). https://doi.org/10.1038/nsmb1207-1118
Issue Date:
DOI: https://doi.org/10.1038/nsmb1207-1118
