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Of Fat flies and Hippos, or the magic of animal size

A stream of papers exposes the molecular nuts and bolts of a mechanism that prevents cells from becoming immortal.

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Figure 1: Schematic view of the Hpo pathway.

Katie Ris

References

  1. Xu, T., Wang, W., Zhang, S., Stewart, R.A. & Yu, W. Development 121, 1053–1063 (1995).

    CAS  Google Scholar 

  2. Justice, R.W., Zilian, O., Woods, D.F., Noll, M. & Bryant, P.J. Genes Dev. 9, 534–546 (1995).

    Article  CAS  Google Scholar 

  3. Tapon, N. et al. Cell 110, 467–478 (2002).

    Article  CAS  Google Scholar 

  4. Harvey, K.F., Pfleger, C.M. & Hariharan, I.K. Cell 114, 457–467 (2003).

    Article  CAS  Google Scholar 

  5. Wu, S., Huang, J., Dong, J. & Pan, D. Cell 114, 445–456 (2003).

    Article  CAS  Google Scholar 

  6. Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D. Cell 122, 421–434 (2005).

    Article  CAS  Google Scholar 

  7. Lai, Z.C. et al. Cell 120, 675–685 (2005).

    Article  CAS  Google Scholar 

  8. Edgar, B.A. Cell 124, 267–273 (2006).

    Article  CAS  Google Scholar 

  9. Neufeld, T.P., de la Cruz, A.F., Johnston, L.A. & Edgar, B.A. Cell 93, 1183–1193 (1998).

    Article  CAS  Google Scholar 

  10. Willecke, M. et al. Curr. Biol. 16, 2090–2100 (2006).

    Article  CAS  Google Scholar 

  11. Bennett, F.C. & Harvey, K.F. Curr. Biol. 16, 2101–2110 (2006).

    Article  CAS  Google Scholar 

  12. Cho, E. et al. Nat. Genet. 38, 1142–1150 (2006).

    Article  CAS  Google Scholar 

  13. Colombani, J., Polesello, C., Josue, F. & Tapon, N. Curr. Biol. 16, 1453–1458 (2006).

    Article  CAS  Google Scholar 

  14. Hamaratoglu, F. et al. Nat. Cell Biol. 8, 27–36 (2006).

    Article  CAS  Google Scholar 

  15. Nolo, R., Morrison, C.M., Tao, C., Zhang, X. & Halder, G. Curr. Biol. 16, 1895–1904 (2006).

    Article  CAS  Google Scholar 

  16. Silva, E., Tsatskis, Y., Gardano, L., Tapon, N. & McNeill, H. Curr. Biol. 16, 2081–2089 (2006).

    Article  CAS  Google Scholar 

  17. Thompson, B.J. & Cohen, S.M. Cell 126, 767–774 (2006).

    Article  CAS  Google Scholar 

  18. McCartney, B.M., Kulikauskas, R.M., LaJeunesse, D.R. & Fehon, R.G. Development 127, 1315–1324 (2000).

    CAS  PubMed  Google Scholar 

  19. Bryant, P.J., Huettner, B., Held, L.I., Jr. Ryerse, J. & Szidonya, J. Dev. Biol. 129, 541–554 (1988).

    Article  CAS  Google Scholar 

  20. Mao, Y. et al. Development 133, 2539–2551 (2006).

    Article  CAS  Google Scholar 

  21. Zilian, O. et al. Development 126, 5409–5420 (1999).

    CAS  PubMed  Google Scholar 

  22. Matakatsu, H. & Blair, S.S. Development 133, 2315–2324 (2006).

    Article  CAS  Google Scholar 

  23. Matakatsu, H. & Blair, S.S. Development 131, 3785–3794 (2004).

    Article  CAS  Google Scholar 

  24. Cho, E. & Irvine, K.D. Development 131, 4489–4500 (2004).

    Article  CAS  Google Scholar 

  25. Strutt, H., Mundy, J., Hofstra, K. & Strutt, D. Development 131, 881–890 (2004).

    Article  CAS  Google Scholar 

  26. Brennecke, J., Hipfner, D.R., Stark, A., Russell, R.B. & Cohen, S.M. Cell 113, 25–36 (2003).

    Article  CAS  Google Scholar 

  27. Hipfner, D.R., Weigmann, K. & Cohen, S.M. Genetics 161, 1527–1537 (2002).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Raisin, S., Pantalacci, S., Breittmayer, J.P. & Leopold, P. Genetics 164, 1015–1025 (2003).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Mikeladze-Dvali, T. et al. Cell 122, 775–787 (2005).

    Article  CAS  Google Scholar 

  30. Blaumueller, C.M. & Mlodzik, M. Mech. Dev. 92, 251–262 (2000).

    Article  CAS  Google Scholar 

  31. Maitra, S., Kulikauskas, R.M., Gavilan, H. & Fehon, R.G. Curr. Biol. 16, 702–709 (2006).

    Article  CAS  Google Scholar 

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Casares, F., Luque, C. & Tavares, M. Of Fat flies and Hippos, or the magic of animal size. Nat Struct Mol Biol 13, 1051–1053 (2006). https://doi.org/10.1038/nsmb1206-1051

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