Rhomboid intramembrane protease structures galore!

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The first structures of an intramembrane serine protease reveal a catalytic His-Ser dyad in a water-filled cavity surrounded by six transmembrane helices, but just how substrate helices gain access to the dyad is controversial.

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Figure 1: Structures of GlpG rhomboid intramembrane serine proteases from E. coli.

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Acknowledgements

This work was supported in part by grants from the National Institute of General Medical Sciences and the National Center for Research Resources, US National Institutes of Health.

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