Lighting up nucleosome spacing

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The mechanism by which ATP-dependent remodeling enzymes act to space nucleosomes is as yet unclear. A new study uses FRET to monitor nucleosome repositioning in real time to address how these enzymes sense when nucleosomes are evenly distributed.

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Figure 1: Possible roles for nucleosome spacing in gene regulation under conditions of different nucleosome spacing.
Figure 2: Mechanisms for nucleosome spacing.

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