Ubiquitin-like protein (Ubl)-specific proteases catalyze Ubl precursor processing and deconjugation. Two recent structural studies of SUMO-specific protease (SENP)–substrate complexes provide new insight into hydrolysis of the peptide bond at the C terminus of SUMO. A kinked, cis configuration for the scissile bond is crucial for proteolysis.
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Huang, D., Schulman, B. Breaking up with a kinky SUMO. Nat Struct Mol Biol 13, 1045–1047 (2006). https://doi.org/10.1038/nsmb1206-1045
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DOI: https://doi.org/10.1038/nsmb1206-1045
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