Deciphering the RNA polymerase II structure: a personal perspective

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This year's Nobel laureate in chemistry is Roger Kornberg. Patrick Cramer gives a personal account of how the Kornberg laboratory determined the structure of the RNA polymerase II core enzyme.

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Figure 1: First sketch of the Pol II core structure.


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I thank my wife for all her support. I apologize to colleagues who helped with the project but who could not be mentioned owing to space constraints. I also apologize to colleagues whose work could not be cited because of the special focus of this essay. I thank M. Bertero for critical reading of the manuscript.

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