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Applying the brakes on gene expression

Nature Structural & Molecular Biology volume 12, pages 10241025 (2005) | Download Citation

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Eukaryotic messenger RNAs are degraded through a pathway that starts with the removal of the poly(A) tail. A recent study shows that cytoplasmic mRNA deadenylation in mammals occurs by the consecutive action of two distinct deadenylases and that degradation of nonsense mRNA involves the same biphasic deadenylation pathway.

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Author information

Affiliations

  1. The author is at the Institute of Cell Biology, University of Berne, Berne, Switzerland. oliver.muehlemann@izb.unibe.ch

    • Oliver Mühlemann

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DOI

https://doi.org/10.1038/nsmb1205-1024

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