Eukaryotic messenger RNAs are degraded through a pathway that starts with the removal of the poly(A) tail. A recent study shows that cytoplasmic mRNA deadenylation in mammals occurs by the consecutive action of two distinct deadenylases and that degradation of nonsense mRNA involves the same biphasic deadenylation pathway.
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Mühlemann, O. Applying the brakes on gene expression. Nat Struct Mol Biol 12, 1024–1025 (2005). https://doi.org/10.1038/nsmb1205-1024
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DOI: https://doi.org/10.1038/nsmb1205-1024