Organisms such as yeast and humans are capable of both nonhomologous end joining (NHEJ) and homologous recombination (HR), but bacteria have typically been assumed to be capable only of HR. A recent study shows that mycobacteria accomplish NHEJ using just two proteins (homologs of the eukaryotic Ku and DNA ligase IV), whereas eukaryotes require many factors.
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the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA. roth@saturn.med.nyu.edu
- Geoffrey R Weller
- , Vicky L Brandt
- & David B Roth
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