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Doing more with less in bacterial DNA repair

Nature Structural & Molecular Biology volume 11, pages 11581159 (2004) | Download Citation

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Organisms such as yeast and humans are capable of both nonhomologous end joining (NHEJ) and homologous recombination (HR), but bacteria have typically been assumed to be capable only of HR. A recent study shows that mycobacteria accomplish NHEJ using just two proteins (homologs of the eukaryotic Ku and DNA ligase IV), whereas eukaryotes require many factors.

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Affiliations

  1. the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA. roth@saturn.med.nyu.edu

    • Geoffrey R Weller
    • , Vicky L Brandt
    •  & David B Roth

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DOI

https://doi.org/10.1038/nsmb1204-1158

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