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Histone H3 Arg2 methylation provides alternative directions for COMPASS

Post-translational modification of histones can profoundly affect chromatin structure and function. The discovery that histone H3 Arg2 methylation is a widespread silencing modification that inhibits histone H3 Lys4 trimethylation extends our understanding of how active and silenced chromatin states are maintained.

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Figure 1: H3R2me2a is found in silenced regions of chromatin and inhibits H3K4me3.

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Klose, R., Zhang, Y. Histone H3 Arg2 methylation provides alternative directions for COMPASS. Nat Struct Mol Biol 14, 1058–1060 (2007). https://doi.org/10.1038/nsmb1107-1058

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