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When extreme negativity is a positive thing

A recent structural study on a human RNA deaminase reveals that inositol hexakisphosphate is a cofactor of the enzyme and is essential for its editing activity.

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Figure 1: Adenosine deamination and IP6.
Figure 2: The IP6-binding site.

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Scadden, D. When extreme negativity is a positive thing. Nat Struct Mol Biol 12, 940–941 (2005). https://doi.org/10.1038/nsmb1105-940

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