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Transmembrane signaling by asymmetry

Nature Structural & Molecular Biology volume 13, pages 861862 (2006) | Download Citation

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The structure of the ligand-binding domains of Vibrio harveyi LuxPQ bound to Autoinducer-2 reveals a dramatic asymmetry in quaternary structure induced by ligand binding. Structures of receptor-sensing domains in both occupied and unoccupied states provide a foundation for postulating mechanisms of transmembrane signaling.

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References

  1. 1.

    et al. Cell 126, 1095–1108 (2006).

  2. 2.

    & Science 311, 1113–1116 (2006).

  3. 3.

    & Nat. Rev. Microbiol. 4, 249–258 (2006).

  4. 4.

    et al. Nature 415, 545–549 (2002).

  5. 5.

    & Mol. Microbiol. 20, 17–25 (1996).

  6. 6.

    BMC Microbiol. 5, 35 (2005).

  7. 7.

    et al. Science 290, 2148–2152 (2000).

  8. 8.

    et al. Science 254, 1342–1347 (1991).

  9. 9.

    et al. J. Mol. Biol. 356, 1193–1206 (2006).

  10. 10.

    , , , & Mol. Cell 18, 507–518 (2005).

  11. 11.

    , & EMBO J. 24, 4247–4259 (2005).

  12. 12.

    , , , & Proc. Natl. Acad. Sci. USA 90, 9939–9943 (1993).

  13. 13.

    , , & J. Bacteriol. 175, 7024–7032 (1993).

  14. 14.

    & Proc. Natl. Acad. Sci. USA 90, 1518–1522 (1993).

  15. 15.

    & Trends Biochem. Sci. 26, 257–265 (2001).

  16. 16.

    & Proc. Natl. Acad. Sci. USA 103, 592–596 (2006).

  17. 17.

    et al. Proc. Natl. Acad. Sci. USA 96, 939–944 (1999).

  18. 18.

    & Proc. Natl. Acad. Sci. USA 101, 627–631 (2004).

  19. 19.

    & Biochemistry 33, 629–634 (1994).

  20. 20.

    & Nature 442, 270–275 (2006).

Download references

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Affiliations

  1. Ann M. Stock is at the Center for Advanced Biotechnology and Medicine, the Department of Biochemistry, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, and the Howard Hughes Medical Institute, Piscataway, New Jersey 08854, USA. stock@cabm.rutgers.edu

    • Ann M Stock

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DOI

https://doi.org/10.1038/nsmb1006-862

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