Many translation initiation inhibitors block transfer RNA binding or placement in the ribosome. Structures of kasugamycin bound to the bacterial ribosome now indicate that it instead blocks proper mRNA placement.
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Mankin, A. Antibiotic blocks mRNA path on the ribosome. Nat Struct Mol Biol 13, 858–860 (2006). https://doi.org/10.1038/nsmb1006-858
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DOI: https://doi.org/10.1038/nsmb1006-858
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