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Antibiotic blocks mRNA path on the ribosome

Nature Structural & Molecular Biology volume 13, pages 858860 (2006) | Download Citation

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Many translation initiation inhibitors block transfer RNA binding or placement in the ribosome. Structures of kasugamycin bound to the bacterial ribosome now indicate that it instead blocks proper mRNA placement.

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References

  1. 1.

    & Biochemistry 29, 5881–5889 (1990).

  2. 2.

    & Nature 254, 34–38 (1975).

  3. 3.

    , & J. Biol. Chem. 254, 9085–9089 (1979).

  4. 4.

    & J. Mol. Biol. 211, 135–145 (1990).

  5. 5.

    et al. Nat. Struct. Mol. Biol. 13, 871–878 (2006).

  6. 6.

    et al. Nat. Struct. Mol. Biol. 13, 879–886 (2006).

  7. 7.

    et al. Science 310, 827–834 (2005).

  8. 8.

    et al. EMBO J. 20, 1829–1839 (2001).

  9. 9.

    et al. Mol. Cell 13, 113–124 (2004).

  10. 10.

    & Biochem. Biophys. Res. Commun. 49, 951–957 (1972).

  11. 11.

    & J. Mol. Biol. 70, 41–55 (1972).

  12. 12.

    , , & Nucleic Acids Res. 20, 563–571 (1992).

  13. 13.

    , , , & Nucleic Acids Res. 32, 3354–3363 (2004).

  14. 14.

    et al. Cell 103, 1143–1154 (2000).

Download references

Author information

Affiliations

  1. Alexander Mankin is at the Center for Pharmaceutical Biotechnology, The University of Illinois, 900 S. Ashland Ave., Rm. 3056, Chicago, Illinois 60607, USA. shura@uic.edu

    • Alexander Mankin

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DOI

https://doi.org/10.1038/nsmb1006-858

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