DNA helicases unwind DNA by a number of mechanisms in which conformational change seems to be of central importance. Characterization of two β-hairpins and fluorescence resonance energy transfer studies of protein-DNA interactions in the minichromosome maintenance proteins afford new insights into the molecular mechanisms of these proteins.
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Acknowledgements
I thank E. Jenkinson and C. Sanders for useful discussions and am supported by a Biotechnology and Biological Sciences Research Council David Phillips Research Fellowship.
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Chong, J. Learning to unwind. Nat Struct Mol Biol 12, 734–736 (2005). https://doi.org/10.1038/nsmb0905-734
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DOI: https://doi.org/10.1038/nsmb0905-734
