Many proteins are marked for destruction by covalent attachment of a polyubiquitin chain that directs binding of the modified molecule to the proteasome. A new report demonstrates that an unstructured region of the substrate must also be recognized to begin proteolytic engagement.
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Kenniston, J., Sauer, R. Signaling degradation. Nat Struct Mol Biol 11, 800–802 (2004). https://doi.org/10.1038/nsmb0904-800
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DOI: https://doi.org/10.1038/nsmb0904-800