Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Resolving integral questions in site-specific recombination

Nature Structural & Molecular Biology volume 12, pages 641–643 (2005)Cite this article

Two long-awaited structures of serine and tyrosine site-specific recombinases bound to DNA show how reactions that are basically the same can be carried out in surprisingly different ways.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Generalized mechanism of tyrosine DNA recombinases.
Figure 2: Models for serine recombinase–mediated strand exchange.

References

  1. Mizuuchi, K. & Baker, T.A. in Mobile DNA II (eds. Craig, N.L., Craigie, R., Gellert, M. & Lambowitz, A.M.) 12–23 (ASM Press, Washington, DC, 2002).

    Book  Google Scholar 

  2. Biswas, T. et al. Nature 435, 1059–1066 (2005).

    Article  CAS  Google Scholar 

  3. Li, W. et al. Science, published online 30 June 2005 (0:11120641).

  4. Azaro, M.A. & Landy, A. in Mobile DNA II (eds. Craig, N.L., Craigie, R., Gellert, M. & Lambowitz, A.M.) 118–148 (ASM Press, Washington, DC, 2002).

    Book  Google Scholar 

  5. Chen, Y. & Rice, P.A. Annu. Rev. Biophys. Biomol. Struct. 32, 135–159 (2003).

    Article  CAS  Google Scholar 

  6. Sherratt, D.J. et al. Phil. Trans. R. Soc. Lond. B 359, 61–69 (2004).

    Article  CAS  Google Scholar 

  7. Van Duyne, G. in Mobile DNA II (eds. Craig, N.L., Craigie, R., Gellert, M. & Lambowitz, A.M.) 93–117 (ASM Press, Washington, DC, 2002).

    Book  Google Scholar 

  8. Wigley, D.B. Structure 6, 543–548 (1998).

    Article  CAS  Google Scholar 

  9. Guo, F., Gopaul, D.N. & van Duyne, G.D. Nature 389, 40–46 (1997).

    Article  CAS  Google Scholar 

  10. Rowland, S.J., Stark, W.M. & Boocock, M.R. Mol. Microbiol. 44, 607–619 (2002).

    Article  CAS  Google Scholar 

  11. Smith, M.C. & Thorpe, H.M. Mol. Microbiol. 44, 299–307 (2002).

    Article  CAS  Google Scholar 

  12. Grindley, N.D.F. in Mobile DNA II (eds. Craig, N.L., Craigie, R., Gellert, M. & Lambowitz, A.M.) 272–302 (ASM Press, Washington, DC, 2002).

    Book  Google Scholar 

  13. Stark, W.M., Sherratt, D.J. & Boocock, M.R. Cell 58, 779–790 (1989).

    Article  CAS  Google Scholar 

  14. Yang, W. & Steitz, T.A. Cell 82, 193–207 (1995).

    Article  CAS  Google Scholar 

  15. Rice, P.A. & Steitz, T.A. EMBO J. 13, 1514–1524 (1994).

    Article  CAS  Google Scholar 

  16. Sanders, E.R. & Johnson, R.C. J. Mol. Biol. 340, 753–766 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, 60615, Illinois, USA

    Phoebe A Rice

Authors
  1. Phoebe A Rice
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rice, P. Resolving integral questions in site-specific recombination. Nat Struct Mol Biol 12, 641–643 (2005). https://doi.org/10.1038/nsmb0805-641

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0805-641

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing